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GLP-1 receptor agonists got their start in an unlikely place: the mouth of a lizard

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Finally, a single study found a non-significant trend toward increased CSF levels of neuroregulins (which belong to the Epidermal Growth Factor or EGF family) in PD patients (Pankonin et al., 2009)

However, clinical observations and patient-reported outcomes from weight loss trials have documented improvements in joint symptoms among individuals taking these medications